PF-00356231 hydrochloride is a specific, non-peptidic, non-zinc chelating ligand and inhibitor of matrix metalloproteinase MMP-12 ( IC 50 =1.4 μM). PF-00356231 hydrochloride binds to MMP-12 and forms PF-00356231/MMP-12 complex. PF-00356231 hydrochloride shows potency against MMP-13 , MMP-8 , MMP-9 , MMP-3 with IC 50 s of 0.00065, 1.7, 0.98, 0.39 μM, respectively In Vitro PF-00356231 hydrochloride against MMP-12/13 can be affected significantly by the presence of acetohydroxamate (AH). PF-00356231 hydrochloride decreases the IC 50 values of MMP-12 (0.014 μM) and MMP-13 (0.27 μM) in the presence AH. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:MMP-12 1.4 μM (IC 50 ) MMP13 0.65 nM (IC 50 ) MMP-3 0.39 μM (IC 50 ) MMP-8 1.7 μM (IC 50 ) MMP-9 0.98 μM (IC 50 )