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Product introduction

R-268712 是一种口服有效的选择性 ALK-5 抑制剂，其 IC50 值为 2.5 nM。R-268712 能以剂量依赖的方式抑制 Smad3 的磷酸化，其 IC50 值为 10.4 nM。R-268712 通过抑制TGF-β 的信号传导来抑制肾小球肾炎以及肾小球硬化，可用于肾脏纤维化和癌症的研究。 R-268712 is an orally active and selective ALK-5 inhibitor, with an IC50 of 2.5 nM. R-268712 inhibits the phosphorylation of Smad3 in a dose-dependent manner with an IC50 of 10.4 nM. R-268712 suppresses glomerulonephritis as well as glomerulosclerosis by inhibiting TGF-β signaling, which can be used in studies of renal fibrosis and cancer.

Specs ⸢ View details ⸥

Chinese name

R 268712,TGF-βRI抑制剂

English name

R 268712

Chinese alias

4-[2-氟-5-[3-(6-甲基-2-吡啶基)-1H-吡唑-4-基]苯基] -1H-吡唑-1-乙醇

English alias

CAS number

879487-87-3

molecular formula

C20H18FN5O

molecular weight

363.39 g/mol

Exact mass

≥98%(HPLC)

PSA

79.600 Å²

Logp

2.200

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R 268712, TGF-βRIinhibitor 100mg

Name: R 268712, TGF-βRIinhibitor 100mg
Brand: 阿拉丁
SKU: R286557-100mg

R 268712, TGF-βRIinhibitor 100mg; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: 100mg; ≥98%; HPLC.

item number：R286557-100mg

Product model：100mg

level： 100mg; ≥98%; HPLC

Lead Time：30days

sold 805 Items

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100mg

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R 268712, TGF-βRIinhibitor 100mg

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