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Product introduction

Rostafuroxin (PST 2238) 是一种洋地黄毒苷衍生物，一种口服有效的 Na+,K+-ATPase (ATP1A1) 抑制剂。Rostafuroxin 与 ATP1A1 胞外域特异性结合，并阻断呼吸道合胞病毒 (RSV) 触发的 EGFR Tyr845 磷酸化。Rostafuroxin 具有抗高血压和抗 RSV 活性。 Rostafuroxin (PST 2238), a digitoxigenin derivative, is an orally active and potent Na+,K+-ATPase (ATP1A1) antognist. Rostafuroxin binds specifically to the ATP1A1 extracellular domain and blocks respiratory syncytial virus (RSV)-triggered EGFR Tyr845 phosphorylation. Rostafuroxin has antihypertensive and anti-RSV activity.

Specs ⸢ View details ⸥

Chinese name

Rostafuroxin,Na + / K + ATPase调节剂

English name

Rostafuroxin

Chinese alias

3β,5β,14β)-21,23-环氧-24-norchola-20,22-二烯-3,14,17-三醇

English alias

CAS number

156722-18-8

molecular formula

C23H34O4

molecular weight

374.51 g/mol

Exact mass

PSA

73.800 Å²

Logp

3.300

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