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名称

rac-CCT-250863 盐酸盐

别名

4-[2-氨基-5-[4-[((二甲基氨基)甲基] -2-噻吩基] -3-吡啶基] -2-[[((2Z))-4,4,4-三氟-1-甲基-2 -丁烯-1-基]氧基]苯甲酰胺盐酸盐

英文别名

4-[2-Amino-5-[4-[(dimethylamino)methyl]-2-thienyl]-3-pyridinyl]-2-[[(2Z)-4,4,4-trifluoro-1-methyl-2-buten-1-yl]oxy]benzamide HCl

英文名称

rac-CCT-250863 HCl

货号

R288579-10mg

包装规格

10mg

浓度

≥98%(HPLC)

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

(Rac)-CCT 250863 盐酸盐是一种具有选择性和可逆性的 NEK 2 抑制剂，其 IC50 值为 0.073 µM。(Rac)-CCT 250863 能诱导细胞周期停滞并有较好的抗癌细胞 (Pomalidomide 敏感/耐药) 增殖活性。(Rac)-CCT 250863 与 Pomalidomide 联用能诱导细胞凋亡，可用于联合抗癌的研究。 rac-CCT-250863 HCl is a selective and reversible inhibitor of NEK 2. rac-CCT-250863 HCl induces cell cycle arrest and has good anti-proliferative activity against cancer cells. rac-CCT-250863 HCl can be used in combination with Pomalidomide to induce apoptosis and can be used in combined anti-cancer studies. Product Describtion: Potent Nek2 inhibitor

生化机理

强大的Nek2抑制剂（IC50 = 73 nM）。与PLK1，MPS1，Cdk2和Aurora A相比，Nek2具有选择性。

CAS号

1364269-06-6(Free base)

分子式

C24H25F3N4O2S(Free base)

分子量

490.54(Free base) g/mol

溶解性

溶于1eq. HCl, 最高浓度 (mg/mL): 49.05, 最高浓度(mM): 100；溶于DMSO, 最高浓度 (mg/mL): 49.05, 最高浓度(mM): 100

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

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rac-CCT-250863 hydrochloride 10mg

Name: rac-CCT-250863 hydrochloride 10mg
Brand: 阿拉丁
SKU: R288579-10mg

rac-CCT-250863 hydrochloride 10mg; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: 10mg; ≥98%; HPLC.

item number：R288579-10mg

Product model：10mg

level： 10mg; ≥98%; HPLC

Lead Time：30days

sold 842 Items

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Specifications：

10mg

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rac-CCT-250863 hydrochloride 10mg

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