RGD肽（GRGDNP）充当整联蛋白-配体相互作用的抑制剂，并在没有信号和整联蛋白介导的细胞聚集的情况下诱导凋亡。研究表明，RGD肽可通过构象变化的激活来促进凋亡，而构象变化可增强caspase-3的激活和自加工。RGD肽可以充当细胞外基质，细胞表面蛋白和整联蛋白的细胞粘附位点。此外，RGD肽可通过细胞粘附抑制ACK-2活化。 RGD peptide (GRGDNP) acts as an inhibitor of integrin-ligand interactions and can induce apoptosis in the absence of signals and integrin-mediated cell clustering. Research demonstrates that RGD peptides promote apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. The RGD peptide can serve as a cell adhesion site of extracellular matrix, cell surface proteins, and integrins. In addition, RGD peptide can inhibit ACK-2 activation through cell adhesion.