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Product introduction

Information Rolapitant Rolapitant (SCH-619734) is a selective and competitive antagonist of human substance P/NK1 receptors with antiemetic activity. It has a high affinity for the human NK1 receptor of 0.66 nM and high selectivity over the human NK2 and NK3 subtypes of >1000-fold, as well as preferential affinity for human, guinea pig, gerbil and monkey NK1 receptors over rat, mouse and rabbit.

Specs ⸢ View details ⸥

Chinese name

Rolapitant, NK 1 受体拮抗剂

English name

Rolapitant

Chinese alias

罗拉吡坦 | 罗拉吡坦

English alias

A04AD14 | BBL023517 | ROLAPITANT [USAN] | Rolapitant [INN] | DDLLIYKVDWPHJI-RDBSUJKOSA-N | SY007106 | (5S,8S)-8-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-8-phenyl-1,9-diazaspiro[4.5]decan-2-one | MS-29288 | STL227859 | (5S,8S)-8-{[(1R)-1-[3,

CAS number

552292-08-7

molecular formula

C25H26F6N2O2

molecular weight

500.48 g/mol

Exact mass

PSA

50.400 Å²

Logp

4.761

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