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名称

Native Bovine RNP/Sm Protein

别名

RNP/Sm（非重组；牛） | 牛RNP/Sm核糖核蛋白复合物 | 牛核小体 | U1小分子细胞核核糖核蛋白抗原

英文别名

Bovine RNP/Sm ribonucleoprotein complex；Natural protein-Bovine Nucleosome | U1-snRNP

货号

R572725-1mg

包装规格

1mg

级别

无载体

浓度

≥95%(SDS-PAGE)

产品介绍

Biochemical Test: ≥95% (SDS-PAGE); Western blot with anti-RNP/Sm autoantibody-positive sample.

生化机理

The U1 small molecule nuclear ribonucleoprotein (U1 snRNP) antigen is an RNP/Sm multi enzyme complex composed of three U1 specific ribonucleoproteins (RNP-A, RNP-C, RNP-68K) and different Sm nucleoproteins (B/B ', D, E, F, G). RNP/Sm complex is an extractable nuclear antigen (ENA) that targets self reactive B and T cells in various rheumatic diseases. Anti RNP antibodies bind to peptides specific for U1 snRNA (RNP-A, RNP-C, RNP-68K), while anti Sm antibodies can bind to peptides specific for U1, U2, U5, and U4/6 snRNA. High titer anti-U1 snRNP autoantibodies are one of the important criteria for diagnosing mixed connective tissue diseases (MCTD, Sharpe syndrome), with a positivity rate of up to 95% -100%, and antibody titers are correlated with disease activity. This antibody can also be detected in 30% -40% of systemic lupus erythematosus (SLE) patients, but almost always accompanied by anti Sm antibodies. Anti-U1-snRNP autoantibodies can also be found in the serum of patients with other rheumatic and immune diseases, including dermatomyositis (10% -20%), unclassified connective tissue disease (20%), Sjogren's syndrome (20%), scleroderma (7%), and overlap syndrome (27%).

来源

天然

预测分子量

29-35 kDa (RNP subunits), 7-15 kDa (Sm subunits)

SDS-PAGE

29 - 35 kDa (RNP subunits) & 7 - 15 kDa (Sm subunits), under reducing conditions; 29 - 35 kDa (RNP subunits) & 7 - 15 kDa (Sm subunits), under non-reducing conditions.

种属

牛(Bovine)

无动物源

无载体

Yes

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

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「No related articles yet」

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