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Product details

名称

Radioprotectin-1

分子类型

小分子

别名

放射保护素-1

英文名称

Radioprotectin-1

货号

R651252-5mg

包装规格

5mg

浓度

≥99%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

Radioprotectin-1 is a potent and specific nonlipid agonist of lysophosphatidic acid receptor 2 (LPA 2 ) , with an EC 50 value of 25 nM for murine LPA 2 subtype In Vitro Radioprotectin-1 is a potent agonist of LPA 2 with an EC 50 of 5 pM and functions as a full agonist at the human ortholog of LPA 2. Radioprotectin-1 (0-3 μM; 15 minutes) effectively reduces apoptosis induced by γ-irradiation and the radiomimetic drug Adriamycin in cells that expressed LPA 2 either endogenously or after transfection. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: MEF cells , IEC-6 cells Concentration: 0 μM, 0.1 μM, 0.3 μM, 1.0 μM,3 μM Incubation Time: 15 minutes Result: Protected cells from apoptosis by γ-irradiation- and the radiomimetic chemotherapeutic\nAdiamycin. In Vivo Radioprotectin-1 is a high-potency specific agonist of the murine LPA 2 GPCR . Radioprotectin-1 (0.1 mg/kg, 0.3 mg/kg; s.c.; every 12 hours; for 3 days) decreases the mortality of C57BL/6 mice in models of the hematopoietic acute radiation syndromes (HE-ARS) and gastrointestinal acute radiation syndromes (GI-ARS) . Radioprotectin-1 exerts its radioprotective and radiomitigative action through specific activation of the upregulated LPA 2 GPCR in Lgr5 + stem cells . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 8-10 weeks old C57BL/6 female mice bearing total body irradiation (TBI) Dosage: 0.1 mg/kg, 0.3 mg/kg Administration: Subcutaneous injection; every 12 hours; for 3 days Result: Decreased mortality of C57BL/6 mice in models of the HE-ARS and the GI-ARS. Form:Solid IC50& Target:EC50: 25 nM (murine LPA 2 subtype)

生化机理

辐射保护蛋白-1 是溶血磷脂酸受体 2（LPA 2）的一种强效特异性非脂类激动剂，对小鼠 LPA 2 亚型的 EC 50 值为 25 nM。

CAS号

1622006-09-0

分子式

C23H19ClN2O6S

分子量

486.92 g/mol

PubChem编号

77461257

Isomeric SMILES

C1=CC2=C3C(=C1)C(=O)N(C(=O)C3=CC=C2)CCCCNS(=O)(=O)C4=C(C=C(C=C4)Cl)C(=O)O

Smiles

C1=CC2=C3C(=C1)C(=O)N(C(=O)C3=CC=C2)CCCCNS(=O)(=O)C4=C(C=C(C=C4)Cl)C(=O)O

PubChem CID

77461257

溶解性

DMSO : 125 mg/mL (256.72 mM; Need ultrasonic) H2O : <0.1 mg/mL (insoluble)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

486.065 Da

单同位素质量Monoisotopic Mass

486.065 Da

拓扑极表面积Topological Polar Surface Area

129.000 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

845.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

3.700

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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