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Product details

名称

RIP2 kinase inhibitor 2

分子类型

小分子

别名

RIP2 激酶抑制剂 2

英文名称

RIP2 kinase inhibitor 2

货号

R651935-5mg

包装规格

5mg

浓度

≥99%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

RIP2 kinase inhibitor 2 is a receptor interacting protein-2 ( RIP2 ) kinase inhibitor extracted from patent WO/2014043437 A1, compound example 9. In Vitro RIP2 kinase inhibitor 2 is a novel prodrug of a quinazolyl amine that inhibits RIP2 kinase. Receptor interacting protein-2 (RIP2) kinase is a TKL family serine/threonine protein kinase involved in innate immune signaling. Following activation, RIP2 kinase associates with NODI or NOD2 and appears to function principally as a molecular scaffold to bring together other kinases (TAK1, ΙΚΚα/β/γ) involved in NF-κΒ and mitogen-activated protein kinase activation. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:RIP2 Kinase

生化机理

RIP2 激酶抑制剂 2 是一种受体互作蛋白-2（RIP2）激酶抑制剂，提取自专利 WO/2014043437 A1，化合物实例 9。

CAS号

1581270-11-2

分子式

C21H28N4O4S

分子量

432.54 g/mol

PubChem编号

73426595

Isomeric SMILES

CC1=C(NN=C1NC2=C3C=C(C(=CC3=NC=C2)OCCOC)S(=O)(=O)C(C)(C)C)C

IIUPAC Name

6-tert-butylsulfonyl-N-(4,5-dimethyl-1H-pyrazol-3-yl)-7-(2-methoxyethoxy)quinolin-4-amine

INCHI

1S/C21H28N4O4S/c1-13-14(2)24-25-20(13)23-16-7-8-22-17-12-18(29-10-9-28-6)19(11-15(16)17)30(26,27)21(3,4)5/h7-8,11-12H,9-10H2,1-6H3,(H2,22,23,24,25)

InChi Key

QODPGRHWJBWTJC-UHFFFAOYSA-N

Smiles

CC1=C(NN=C1NC2=C3C=C(C(=CC3=NC=C2)OCCOC)S(=O)(=O)C(C)(C)C)C

PubChem CID

73426595

溶解性

DMSO : 5 mg/mL (11.56 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

432.183 Da

单同位素质量Monoisotopic Mass

432.183 Da

拓扑极表面积Topological Polar Surface Area

115.000 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

663.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

3.200

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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