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Product details

名称

RO0270608

英文名称

RO0270608

货号

R654494-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

-80℃储存

运输条件

超低温冰袋运输

产品介绍

RO0270608, the active metabolite of R411, is a dual alpha4beta1-alpha4beta7 (α4β1/α4β7) integrin antagonist. Antiinflammatory activity In Vitro RO0270608 inhibits α4/β7 mediated cell adhesion with an IC50 of 33 nM. In a human T-cell VCAM/anti CD3 costimulation assay RO0270608 causes a pronounced inhibition of T-cell proliferation (IC 50 =30 nM). MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo In a murine OVA-model of airway inflammation, RO0270608 i.n. abolishes allergen-induced inflammatory cell accumulationMCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:α4β1 α4β7

生化机理

RO0270608是R411的活性代谢物，是一种双重α4β1-α4β7（α4β1/α4β7）整合素拮抗剂。抗炎活性。

CAS号

220846-33-3(DMSO)

分子式

C24H19Cl3N2O4

分子量

505.78 g/mol

Smiles

CC1=C(C(=CC=C1)Cl)C(=O)NC(CC2=CC=C(C=C2)NC(=O)C3=C(C=CC=C3Cl)Cl)C(=O)O

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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