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Product details

名称

6RK73

英文名称

6RK73

货号

R654499-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

-80℃储存

运输条件

超低温冰袋运输

产品介绍

6RK73 is a covalent irreversible and specific UCHL1 inhibitor with an IC 50 of 0.23 µM. 6RK73 shows almost no inhibition of UCHL3 (IC 50 =236 µM). 6RK73 specifically inhibit UCHL1 activity in breast cancer In Vitro 6RK73 (5 μM; 1-3 hours) treatment displays strong inhibition of the TGFβ-induced pSMAD2 and pSMAD3, and a decrease of TβRI and total SMAD protein levels in MDA-MB-436 cells. ?\n6RK73(5 μM; 24-48 hours) results migration significantly slower than the DMSO control group in MDA-MB-436 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: MDA-MB-436 cells Concentration: 5 µM Incubation Time: 24, 48 hours Result: Migrated significantly slower than the DMSO control group Western Blot AnalysisCell Line: MDA-MB-436 cells Concentration: 5 µM Incubation Time: 1, 2, 3 hours Result: Displayed strong inhibition of the TGFβ-induced pSMAD2 and pSMAD3, and a decrease of TβRI and total SMAD protein levels. In Vivo 6RK73 displays a potent inhibition of breast cancer extravasation in zebrafish . MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: 0.23 µM (UCHL1), 236 µM (UCHL3)

生化机理

6RK73 是一种共价不可逆特异性 UCHL1 抑制剂，其 IC 50 为 0.23 µM。6RK73 对 UCHL3 几乎没有抑制作用（IC 50 =236 µM）。6RK73 能特异性抑制乳腺癌中 UCHL1 的活性。

CAS号

1895050-66-4(DMSO)

分子式

C13H17N5O2S

分子量

307.37 g/mol

Smiles

C1CN(CC1C(=O)NC2=NC=C(S2)N3CCOCC3)C#N

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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