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名称

Ralaniten triacetate

别名

拉拉尼汀三乙酸酯

英文名称

Ralaniten triacetate

货号

R655532-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

-80℃储存

运输条件

超低温冰袋运输

产品介绍

Ralaniten triacetate (EPI-506), the pro-agent of Ralaniten, is a first-in-class, orally active androgen receptor (AR) N-terminal domain (NTD) inhibitor. Ralaniten triacetate shows activity against both full length and resistance-related AR species, including AR-v7. In Vitro Ralaniten triacetate (EPI-506) targets the N-terminal domain of the androgen receptor (AR), and is used for metastatic castration-resistant prostate cancer (mCRPC) research. EPI-506 is a first-in-class, highly-specific small molecule that binds to a novel target on the AR, the N-terminal domain (NTD) and directly inhibits AR transcriptional activity by blocking the interaction of the AR with transcriptional proteins. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

生化机理

Ralaniten triacetate（EPI-506）是 Ralaniten 的原制剂，是第一类口服活性雄激素受体（AR）N-末端结构域（NTD）抑制剂。Ralaniten triacetate 对全长和抗药性相关的 AR 种类都有活性，包括

CAS号

1637573-04-6(DMSO)

分子式

C27H33ClO8

分子量

521 g/mol

Smiles

CC(=O)OCC(COC1=CC=C(C=C1)C(C)(C)C2=CC=C(C=C2)OCC(CCl)OC(=O)C)OC(=O)C

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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