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Product details

名称

RP 70676

分子类型

小分子

英文名称

RP 70676

货号

R655832-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

-80℃储存

运输条件

超低温冰袋运输

产品介绍

RP 70676 is a potent inhibitor of ACAT , with IC 50 of 25 and 44 nM for rat and rabbit ACAT . In Vitro RP 70676 is a potent inhibitor of rabbit arterial ACAT (IC 50 = 40 nM) and has been shown to be an effective inhibitor of ACAT derived from a number of tissues and species including man. The IC 50 values range from 21 nM for hamster liver ACAT to 108 nM for enzyme from the intestine of cholesterol fed rabbits; in human hepatic tissues the mean IC 50 is 44 nM. In whole cell P388D, murine macrophages the compound has an IC 50 of 540 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo RP 70676 (10 mg/kg, p.o.) is well absorbed with plasma levels in NZW rabbits . MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: 25 nM (Rat ACAT), 44 nM (Rabbit ACAT)

生化机理

RP 70676 是一种强效的 ACAT 抑制剂，对大鼠和家兔 ACAT 的 IC 50 分别为 25 和 44 nM。

CAS号

136609-26-2(DMSO)

分子式

C25H28N4S

分子量

416.58 g/mol

Smiles

CC1=CC(=NN1CCCCCSC2=NC(=C(N2)C3=CC=CC=C3)C4=CC=CC=C4)C

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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