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Product introduction

SAE/SUMO1 (Cell-free assay); SAE/SUMO2 (Cell-free assay) 3 nM; 11 nM In vitro ML-792 is a mechanism-based SUMO-activating enzyme (SAE) inhibitor with nanomolar potency in cellular assays. ML-792 selectively blocks SAE enzyme activity and total SUMOylation, thus decreasing cancer cell proliferation. Induction of the MYC oncogene increases the ML-792-mediated viability effect in cancer cells, thus indicating a potential application of SAE inhibitors in treating MYC-amplified tumors. Cell Research(from reference) Cell lines：HCT116 cells Concentrations：0.5 μM Incubation Time：48 h

Specs ⸢ View details ⸥

Chinese name

ML792

English name

ML792

Chinese alias

English alias

Sulfamic acid,[(1R,2S,4R)-4-[[5-[[1-[(3-bromophenyl)methyl]-1H-pyrazol-3-yl]carbonyl]-4-pyrimidinyl]amino]-2-hydroxycyclopentyl]methyl ester

CAS number

1644342-14-2

molecular formula

C21H23BrN6O5S

molecular weight

551.41 g/mol

Exact mass

≥99%

PSA

171.000 Å²

Logp

2.300

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ML 792 10mM in DMSO 1ml

Name: ML 792 10mM in DMSO 1ml
Brand: 麦克林
SKU: R688348-1ml

Macklin ML 792 10mM in DMSO 1ml, CAS 1644342-14-2, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.

item number：R688348-1ml

Product model：1ml

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Lead Time：30days

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ML 792 10mM in DMSO 1ml

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