- Treatment： 在严重情况下，考虑支持疗法。保持呼吸道通畅和充分水合。抗帕金森药物、苯托品甲磺酸盐以及巴比妥类药物可用于缓解锥体外系症状(A632)。
- exposure pathway： 吸入；皮肤接触；摄入(MSDS, A308)。吸收可能不规律，血浆峰浓度显示个体间差异很大。
- Toxicity summary： 丙嗪是1、2和4型多巴胺受体、5-HT受体2A和2C型、毒蕈碱受体1至5型、α(1)受体和组胺H1受体的拮抗剂。丙嗪的抗精神病作用是由于多巴胺和血清素2型受体的拮抗作用，在血清素5-HT2受体上的活性高于多巴胺2型受体。这可能解释了缺乏锥体外系效应。丙嗪似乎不会阻断下丘脑-漏斗束中的多巴胺，这解释了与典型抗精神病药物或利培酮相比，高催乳素血症的发生率较低。丙嗪也会拮抗毒�碱受体、H1受体和α(1)受体。
- Regulatory information： 新西兰EPA化学品清单状态：10H-吩噻嗪-10-丙胺，N,N-二甲基-，单盐酸盐：没有单独批准，但可在适当的团体标准下使用
- Toxicity Data： LD50: 140 mg/kg (腹腔注射, 小鼠)
- Health Effects： 它主要具有抗胆碱副作用，但锥体外系副作用也不少见。其他影响包括内分泌影响（如男性乳房发育和月经紊乱）、对阳光敏感和溶血性贫血(A308, L1149)。
- Symptoms and Signs： 副作用包括: 锥体外系症状、嗜睡、体重增加、口干、便秘、内分泌效应(如男性乳房发育和月经紊乱)、对阳光敏感和溶血性贫血。
- Other safety information： 化学品评估：IMAP评估 - 10H-吩噻嗪-10-丙胺，N,N-二甲基-，单盐酸盐：人类健康I级评估
- Hazard categories and classifications： 皮肤致敏物 1 (97.6%)
- Carcinogen Classification： 对人类无致癌性迹象（未被IARC列出）。
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Promazine hydrochloride 10mM in DMSO 1ml
Macklin Promazine hydrochloride 10mM in DMSO 1ml, CAS 53-60-1, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.
