- Treatment： 胃肠道去污（即洗胃后使用活性炭）应考虑用于疑似利扎曲坦过量的患者。即使未观察到临床症状，临床和心电图监测也应至少持续12小时。(L1712)
- exposure pathway： 口服后迅速吸收。生物利用度为45%。食物对利扎曲坦的生物利用度没有影响。然而，与食物一起服用利扎曲坦会延迟1小时达到血浆峰浓度的时间。吸收速率不受偏头痛发作的影响。
- Toxicity summary： 曲普坦的抗偏头痛作用涉及三种不同的药理作用：(1)刺激突触前5-HT1D受体，这有助于抑制硬脑膜血管舒张和炎症；(2)通过脑干中5-HT1B/1D受体激动作用直接抑制三叉神经核细胞兴奋性；(3)由于血管5-HT1B受体激动作用导致脑膜、硬脑膜、脑或软脑膜血管收缩。
- Symptoms and Signs： 过量症状包括头晕、昏厥、心脏和血管问题、高血压、大小便失禁、心跳缓慢和呕吐。
- Hazard categories and classifications： 特定靶器官毒性-单次接触-1级（100%）
- Carcinogen Classification： 对人类无致癌性迹象（未被IARC列出）。
- Drug Induced Liver Injury： 参考文献：DOI:10.1016/j.drudis.2019.09.022
- Effects During Pregnancy and Lactation： 对四个欧洲不良反应数据库的回顾发现，有26例报告称，哺乳期间服用曲普坦的妇女出现疼痛、灼烧感的乳头、疼痛的乳房、乳房胀痛和/或疼痛的乳汁排出。疼痛有时很剧烈，偶尔导致乳汁产量减少。随着药物被排出体外，疼痛通常会随时间减轻。作者提出，曲普坦可能导致乳房、乳头和腺泡及导管周围动脉的血管收缩，引起疼痛感和疼痛的乳汁排出反射。
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Research chemical CAS 145202-66-0 10mM 1ml
Research chemical CAS 145202-66-0 10mM 1ml, complete specifications, for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.
