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Product introduction
Ruxolitinib Phosphate (INCB018424, INC424)是Ruxolitinib的磷酸盐形式。Ruxolitinib 是第一个应用于临床的,有效的,选择性JAK1/2抑制剂,在无细胞试验中IC50为3.3 nM/2.8 nM。作用于JAK1,JAK2与作用于JAK3相比,选择性高130多倍。Ruxolitinib 通过毒性线粒体自噬杀死肿瘤细胞。Ruxolitinib 可诱导自噬并增强细胞凋亡。
Chinese name
鲁索利替尼, 酪氨酸蛋白激酶 JAK2 抑制剂
English name
Ruxolitinib phosphate salt
Chinese alias
-
English alias
(R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrilephosphate | Jakavi (TN) | (3R)-3-cyclopentyl-3-(4-(7h-pyrrolo(2,3-d)pyrimidin-4-yl)pyrazol-1-yl)propanenitrile Phosphate (1:1) | HY-50858 | Ruxolitinib phosphate | Ruxo
CAS number
1092939-17-7
molecular formula
C17H21N6O4P
molecular weight
404.4 g/mol
Exact mass
≥98%
PSA
161.000 Ų
Logp
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Ruxolitinib Phosphate 10mM in DMSO 1ml

Ruxolitinib Phosphate 10mM in DMSO 1ml Macklin 1092939-17-7, complete specifications, for production, research, laboratory testing and inspection, digital one-stop procurement platform for scientific materials.

item number:R798288-1ml
Product model:1ml
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Lead Time:30days
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