- Treatment： 胃肠道去污（即洗胃后使用活性炭）应考虑用于疑似利扎曲坦过量的患者。即使未观察到临床症状，临床和心电图监测也应至少持续12小时。(L1712)
- exposure pathway： 口服后迅速吸收。生物利用度为45%。食物对利扎曲坦的生物利用度没有影响。然而，与食物一起服用利扎曲坦会延迟1小时达到血浆峰浓度的时间。吸收速率不受偏头痛发作的影响。
- Toxicity summary： 曲普坦的抗偏头痛作用涉及三种不同的药理作用：(1)刺激突触前5-HT1D受体，这有助于抑制硬脑膜血管舒张和炎症；(2)通过脑干中5-HT1B/1D受体激动作用直接抑制三叉神经核细胞兴奋性；(3)由于血管5-HT1B受体激动作用导致脑膜、硬脑膜、脑或软脑膜血管收缩。
- Symptoms and Signs： 过量症状包括头晕、昏厥、心脏和血管问题、高血压、大小便失禁、心跳缓慢和呕吐。
- Hazard categories and classifications： 特定靶器官毒性-单次接触-1级（100%）
- Carcinogen Classification： 对人类无致癌性迹象（未被IARC列出）。
- Drug Induced Liver Injury： 参考文献：DOI:10.1016/j.drudis.2019.09.022
- Effects During Pregnancy and Lactation： 对四个欧洲不良反应数据库的回顾发现，有26例报告称，哺乳期间服用曲普坦的妇女出现疼痛、灼烧感的乳头、疼痛的乳房、乳房胀痛和/或疼痛的乳汁排出。疼痛有时很剧烈，偶尔导致乳汁产量减少。随着药物被排出体外，疼痛通常会随时间减轻。作者提出，曲普坦可能导致乳房、乳头和腺泡及导管周围动脉的血管收缩，引起疼痛感和疼痛的乳汁排出反射。
Warm reminder：
Because the manufacturer may temporarily adjust product specifications, prices, inventory, parameters and other information without notice, and there are differences in each user's consultation time and procurement needs, the platform reply content is only of reference value within a certain period. Sorry for the inconvenience caused to you, and thank you for your understanding and support! Please consult the online customer service for the latest details. Everything is subject to the real-time reply of the customer service.！
Please check the quantity, appearance and product information in time when you receive the goods. In case of damage, wrong delivery, abnormal quality and other problems, please feel free to contact us.
Service Hotline:400-6226-992 ，We will handle it for you as soon as possible, thank you for your support and trust.！
Rizatriptan phenylzoate 98%(HPLC) 10/mg
Rizatriptan phenylzoate 98%(HPLC) 10/mg Macklin 145202-66-0, available in complete specifications for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials
