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Product introduction

(R)-CR8 (CR8) trihydrochloride 是 Roscovitine 的第二代类似物，是一种有效的 CDK1/2/5/7/9 抑制剂。(R)-CR8 trihydrochloride 抑制 CDK1/cyclin B (IC50=0.09 μM)、CDK2/cyclin A (0.072 μM)、CDK2/cyclin E (0.041 μM)、CDK5/p25 (0.11 μM)、CDK7/cyclin H (1.1 μM)、CDK9/cyclin T (0.18 μM) 和 CK1δ/ε (0.4 μM)。(R)-CR8 trihydrochloride 诱导细胞凋亡并具有神经保护作用。(R)-CR8 trihydrochloride 作为一种分子胶降解剂来消耗细胞周期蛋白 K。 Product description (R)-CR8 (CR8) trihydrochloride, a second-generation analog of Roscovitine, is a potent CDK1/2/5/7/9 inhibitor. (R)-CR8 trihydrochloride inhibits CDK1/cyclin B (IC50=0.09 μM), CDK2/cyclin A (0.072 μM), CDK2/cyclin E (0.041 μM), CDK5/p25 (0.11 μM), CDK7/cyclin H (1.1 μM), CDK9/cyclin T (0.18 μM) and CK1δ/ε (0.4 μM). (R)-CR8 trihydrochloride induces apoptosis and has neuroprotective effect[1][2]. (R)-CR8 trihydrochloride acts as a molecular glue degrader that depletes cyclin K.

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Chinese name

(R)-CR8 三盐酸盐，CDK抑制剂

English name

(R)-CR8 trihydrochloride

Chinese alias

(2R)-2-[[[9-(甲基乙基)-6]-[[[4-(2-吡啶基)苯基]甲基]氨基] -9H-嘌呤-2-基]氨基] -1-丁醇三盐酸盐

English alias

(2R)-2-[[9-(Methylethyl)-6-[[[4-(2-pyridinyl)phenyl]methyl]amino]-9H-purin-2-yl]amino]-1-butanol trihydrochloride

CAS number

1786438-30-9

molecular formula

C24H32Cl3N7O

molecular weight

540.92 g/mol

Exact mass

≥99%(HPLC)

PSA

101.000 Å²

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(R)-CR8 trihydrochloride ≥99%(HPLC) 5mg

Name: (R)-CR8 trihydrochloride ≥99%(HPLC) 5mg
Brand: 麦克林
SKU: R911122-5mg

(R)-CR8 trihydrochloride ≥99%(HPLC) 5mg CAS 1786438-30-9, complete specifications for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.

item number：R911122-5mg

Product model：5mg

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Lead Time：30days

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