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Product introduction
N-苯甲酰甘氨酸是一种 N-酰基甘氨酸,其中酰基指定为苯甲酰基。它作为尿毒症毒素和人类血液血清代谢物的作用已被确认。它是 N-苯甲酰甘氨酸盐的共轭酸。
Chinese name
<i>N</i>-苯甲酰基甘氨酸
English name
2-benzamidoacetic acid
Chinese alias
马尿酸;苯甲酰氨基乙酸
English alias
N-Benzoylglycine | n-benzoyl-glycine | Tox21_111710_1 | (benzoylamino)-Acetate | 2-(Phenylformamido)Acetic Acid | Bz-Gly-OH | Benzoylglycin | Benzoylglycocoll | FT-0660260 | NCGC00159486-02 | TimTec1_002805 | Acido ippurico [Italian] | HIPPURIC ACID [INCI
CAS number
495-69-2
molecular formula
C9H9NO3
molecular weight
179.17
Exact mass
≥98%
PSA
66.4
Logp
0.3
Safety
  • Treatment: 通常需要透析以缓解尿毒症综合征的症状,直到肾脏功能恢复正常为止。
  • Hazard summary: 甘氨酸与苯甲酸的共轭物,以及甲苯的人类代谢物;已作为职业性接触甲苯(在没有二甲苯和苯乙烯暴露的情况下)的生物标志物在尿液中测得;[NIOSH 分析手册] 可能引起刺激;[Alfa Aesar MSDS]
  • exposure pathway: 内源性、摄入、皮肤接触(接触)
  • Toxicity summary: 如马尿酸等尿毒症毒素通过有机离子转运体(特别是 OAT3)主动运输到肾脏中。尿毒症毒素水平的升高可以刺激活性氧的产生。这似乎是由尿毒症毒素直接结合或抑制酶 NADPH 氧化酶(特别是在肾脏和心脏中丰富的 NOX4)介导的 (A7868)。活性氧可以诱导几种不同的 DNA 甲基转移酶 (DNMTs),这些酶参与已知为 KLOTHO 蛋白的沉默。KLOTHO 已被确定为在抗衰老、矿物质代谢和维生素 D 代谢方面发挥重要作用。多项研究表明,在急性或慢性肾脏疾病期间,对 h...
  • Regulatory information: 新西兰 EPA 化学品状态清单:N-苯甲酰甘氨酸:没有单独的批准,但可以在适当的群体标准下使用
  • Health Effects: 慢性暴露于尿毒症毒素可导致多种状况,包括肾损伤、慢性肾脏病和心血管疾病。
  • ecotoxicity value: USDA APHIS 化学品效应:collection=usda_chemeffect&query_type=synonym&query='^495-69-2$'
  • Symptoms and Signs: 作为一种尿毒症毒素,该化合物可引起尿毒症综合征。尿毒症综合征可能影响身体的任何部分,并可能导致恶心、呕吐、食欲不振和体重减轻。它还可能导致精神状态改变,如困惑、意识降低、烦躁、精神病、癫痫发作和昏迷。异常出血,例如从轻微伤害中自发或大量出血也可能发生。心脏问题,如心律不齐、围绕心脏的囊膜发炎(心包炎)以及心脏压力增加可在尿毒症综合征患者中看到。由于肺部和胸壁之间的空间积液导致的呼吸困难也可能存在。
  • Other safety information: 化学评估:评价 - 不太需要进一步监管以管理环境风险的化学品
  • Hazard categories and classifications: STOT SE 3 (93.1%)
  • Carcinogen Classification: 对人类无致癌性指示(未列入 IARC)。
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Research chemical CAS 495-69-2 BR 99% 500g

Yuanye Research chemical CAS 495-69-2 BR 99% 500g, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.

item number:S20161-500g
Product model:500g
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