Nattokinase is a potent fibrinolytic enzyme. Nattokinase can break down blood clots by directly hydrolyzing fibrin and plasmin substrate. Nattokinase can be used for the research of cardiovascular diseases. In Vitro Nattokinase dissolves 94% blood clot at ten minutes and degrades the fibrin clot after two hours of incubation. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Nattokinase (150-250 mg/kg; oral gavage twice daily for 2 days) exhibits fibrinolytic activity and dissolves blood clots in vivo. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Sprague-Dawley (SD) rats (180-220 g) are injected κ-CarrageenanDosage: 150, 250 mg/kg Administration: Oral gavage twice daily for 2 days Result: Increased the plasma concentration of fibrin/fibrinogen degradation products (FDPs) and D-Dimer in a dose-dependent manner. Decreased the fraction of the vessel cross section occupied by thrombosis. Form:Solid