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Product introduction
物理描述 | 丙磺舒表现为无味的白色或几乎白色的结晶性粉末。略带苦味;愉悦的后味。(NTP, 1992)
Chinese name
丙磺舒, 溶质运载家族 22 成员 11 抑制剂
English name
4-(dipropylsulfamoyl)benzoic acid
Chinese alias
-
English alias
PROBENECID (USP IMPURITY) | Benemid; Benecid; Benuryl | Benzoic acid, 4-((dipropylamino)sulfonyl)- | PROBENECID [WHO-IP] | Spectrum3_000554 | PROBAMPACIN COMPONENT PROBENECID | PROBENECID COMPONENT OF PROBAMPACIN | Probenecide | DTXCID901188 | Probexin |
CAS number
57-66-9
molecular formula
C13H19NO4S
molecular weight
285.36
Exact mass
-
PSA
83.1
Logp
3.2
Safety
  • DOT label: 毒药
  • Health hazard: 急/慢性危害:该化合物在加热分解时会排放出非常有毒的SOx和NOx烟雾。(NTP, 1992)
  • reactive group: 磺酸盐、膦酸盐和硫代膦酸盐,有机
  • First aid measures: 食入:不要催吐。如果受害者意识清醒且没有抽搐,给予1-2杯水稀释化学物质,并立即呼叫医院或中毒控制中心。如果医生建议,准备将受害者送往医院。如果受害者抽搐或昏迷,不要经口给予任何东西,确保受害者的气道通畅,让受害者侧卧,头部低于身体。不要催吐。立即将受害者送往医院。(NTP, 1992)
  • fire hazard: 该化学品的闪点数据不可用。它可能是可燃的。(NTP, 1992)
  • fire fighting: 涉及此材料的火灾可以使用干化学灭火器、二氧化碳或哈龙灭火器控制。(NTP, 1992)
  • Hepatotoxicity: 可能性评分: D(可能是临床上明显的肝损伤的罕见原因)。
  • Special Reports: DHHS/NTP;丙磺舒的毒理学与致癌性研究在F344/N大鼠和B6C3F1小鼠中(灌胃研究)技术报告系列第395号(1991) NIH出版物第91-2850号
  • reactivity profile: PROBENECID可能对光敏感(NTP, 1992)。
  • Isolation and evacuation: 火灾:如果涉及罐、铁路罐车或公路罐车,应在所有方向上隔离800米(1/2英里);同时,考虑在所有方向上初始疏散800米(1/2英里)。(ERG, 2024)
  • FDA Requirements: 《具有治疗等效性评价的批准药物产品清单》确定了当前上市的处方药产品,包括丙磺舒,这些产品根据FDA在《联邦食品、药品和化妆品法》第505和507节下基于安全性和有效性批准的。
  • Other safety information: 化学品评估:IMAP评估 - 4-[(二丙基氨基)磺酰基]苯甲酸:人体健康I级评估
  • Air and water reaction: 不溶于水。
  • Hazard categories and classifications: 急性毒性 4 (100%)
  • Non-fire leakage response: 储存注意事项:您应将此材料在室温下储存并避光保存。(NTP, 1992)
  • Personal protective equipment (PPE): 推荐呼吸器:在称量和稀释纯测试化学品时,佩戴NIOSH批准的半面罩呼吸器,配备有机蒸气/酸性气体 cartridges(专门用于有机蒸气、HCl、酸性气体和SO2)和粉尘/雾过滤器。(NTP,1992)
  • Antidote and first aid: 在急性丙磺舒过量情况下,建议通过催吐或洗胃立即排空胃。
  • Carcinogen Classification: 摘要:在这2年的灌胃研究条件下,接受玉米油中100或400 mg/kg剂量的雄性或雌性F344/N大鼠没有显示丙磺舒致癌活性的证据。接受玉米油中100或400 mg/kg丙磺舒的雄性B6C3F1小鼠没有显示丙磺舒致癌活性的证据。基于肝细胞腺瘤发病率的增加,雌性B6C3F1小鼠有丙磺舒致癌活性的某些证据。
  • Drug Induced Liver Injury: 参考文献:DOI:10.1016/j.drudis.2019.09.022
  • Populations at Special Risk: ... /丙磺舒/ 禁用于有肾结石病史的患者,尤其是尿酸结石患者,因为它可能加重或导致这种情况。
  • Effects During Pregnancy and Lactation: 截至修订日期,未找到相关已发表信息。
Technical Documents
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Related
upstream information
Manufacturing method:
甲苯(CID:1140);氯磺酸(CID:24638);对羧基苯磺酸(CID:69469);二正丙胺(CID:8902);对羧基苯磺酰氯(CID:82385)
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Research chemical CAS 57-66-9 98% 100g

Research chemical CAS 57-66-9 98% 100g, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.

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