具有四环二萜糖苷结构的抗真菌代谢物。它是一种高效的真核蛋白质合成抑制剂，对真菌翻译机制具有选择性。伸长因子eEF-2是索达林的分子靶标。它通过以类似于细菌系统中夫西地酸的方式稳定EF2-核糖体复合物来阻止核糖体易位。其他细胞成分（包括rpP0，这是核糖体大亚基茎的必需蛋白）也参与了其作用机理。Sordarin抑制致病性真菌白色念珠菌，光滑念珠菌和新形成梭菌中的体外翻译。除了具有治疗潜力外，Sordarin是分析蛋白质翻译事件的有用工具。 An antifungal metabolite possessing a tetracyclic diterpene glycoside structure. It is a highly potent inhibitor of eukaryotic protein synthesis with selectivity for the fungal translation machinery. The elongation factor eEF-2 is the molecular target for sordarin. It blocks ribosomal translocation by stabilizing the EF2-ribosome complex in a manner similar to that of fusidic acid in the bacterial system. Additional cellular components (including rpP0, which is an essential protein of the ribosomal large subunit stalk) are involved in its mechanism of action. Sordarin inhibits in vitro translation in the pathogenic fungi C. albicans, C. glabrata, and C. neoformans. In addition to its therapeutic potential, sordarin is a useful tool for the analysis of protein translation events.