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Sandoz 58-035是Acyl-CoA胆固醇酰基转移酶（ACAT）的抑制剂。Sandoz 58-035在培养的动脉平滑肌细胞中还抑制胆固醇酯的积累，并抑制胆固醇的酯化程度达95％。Sandoz 58-035 不会影响肠道的甘油三酸酯代谢。Sandoz 58-035用于诱导小鼠腹膜巨噬细胞中未折叠蛋白应答（UPR）和模式识别受体（PRR）的同时激活。Sandoz 58-035也称为SA 58-035，和3- [癸基二甲基甲硅烷基] -N- [2-（4-甲基苯基）-1-苯乙基]丙酰胺。 Sandoz 58-035 is an inhibitor of Acyl-CoA cholesterol acyltransferase (ACAT). Sandoz 58-035 also inhibits the accumulation of cholesteryl esters and inhibits the esterification of cholesterol by 95% in arterial smooth muscle cells in culture. Sandoz 58-035 does not affect the triglyceride metabolism by the gut. Sandoz 58-035 was used to induce simultaneous activation of unfolded protein response (UPR) and pattern recognition receptors (PRRs) in mouse peritoneal macrophages. Sandoz 58-035 is also known as SA 58-035, and 3-[Decyldimethylsilyl]-N-[2-(4-methylphenyl)-1-phenethyl]propanamide.

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Chinese name

Sandoz 58-035

English name

Sandoz 58-035

Chinese alias

3-[癸基二甲基甲硅烷基] -N- [2-（4-甲基苯基）-1-苯乙基]丙酰胺 | 山德士 58-035

English alias

3-(Decyldimethylsilyl)-N-(2-(4-methylphenyl)-1-phenylethyl)propanamide | 3-[decyl(dimethyl)silyl]-N-[2-(4-methylphenyl)-1-phenylethyl]propanamide | SA 58-035

CAS number

78934-83-5

molecular formula

C30H47NOSi

molecular weight

465.79 g/mol

Exact mass

≥97%

PSA

29.100 Å²

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