B-Raf IN 10 (Compound C09) is a BRAF inhibitor with an IC 50 between 50 and 100 nM. B-Raf IN 10 shows antitumor activity In Vitro B-Raf IN 10 (Compound C09) (1 μM) shows more than 89% inhibition against BRAF and BRAF V600E. B-Raf IN 10 shows an IC 50 between 50 and 100 nM against BRAF, less than 50 nM against BRAF V600E. B-Raf IN 10 (72 h) inhibits A375 and SK-MEL-28 cells growth but not CHL-1 and SK-MEL-31 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: A375, SK-MEL-28, SK-MEL-31 and CHL-1 Concentration: Incubation Time: 72 h Result: Showed inhibition with IC 50 s less than 500 nM against A375 and SK-MEL-28 cells, and showed no inhibition against CHL-1 and SK-MEL-31. Form:Solid IC50& Target:BRAF-V600E