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Product introduction

SP600125是泛JNK抑制剂，对JNK1，JNK2和JNK3的IC50分别为40 nM，40 nM和90 nM，比对MKK4和MKK3，MKK6，PKB，PKCα的抑制性高10倍和超过25倍。A potent, selective and reversible inhibitor of JNK1, JNK-2, and JNK-3 SP600125 is a broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 40 nM, 40 nM and 90 nM in cell-free assays, respectively; 10-fold greater selectivity against MKK4, 25-fold greater selectivity against MKK3, MKK6, PKB, and PKCα, and 100-fold selectivity against ERK2, p38, Chk1, EGFR etc. A potent, selective and reversible inhibitor of JNK1, JNK-2, and JNK-3

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Chinese name

蒽[1,9-cd]吡唑-6(2H)-酮, 丝裂原活化蛋白激酶 10 抑制剂

English name

SP600125

Chinese alias

English alias

CAS number

129-56-6

molecular formula

C14H8N2O

molecular weight

220.233 g/mol

Exact mass

PSA

45.800 Å²

Logp

2.700

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