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Product introduction

SB431542是一种有效的，选择性的ALK5抑制剂，IC50为94 nM，对ALK5的作用比对p38、 MAPK和其他激酶强100倍。A specific and selective inhibitor of TGF-β type I ALK receptors and Smad3. SB-431542被用于研究结直肠肿瘤细胞中血小板衍生生长因子受体B表达与TGF-β途径激活的相关性。它被用于研究TGF-β信号传导在调节细胞外基质和成肌细胞分化中的作用。 SB431542 is a potent and selective inhibitor of ALK5 with IC50 of 94 nM in a cell-free assay, 100-fold more selective for ALK5 than p38 MAPK and other kinases. A specific and selective inhibitor of TGF-β type I ALK receptors and Smad3.

Specs ⸢ View details ⸥

Chinese name

SB431542,ALK抑制剂, 激活素 A 受体 1C 型抑制剂

English name

SB431542

Chinese alias

English alias

4-(4-(benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide | 4-[4-(1,3-BENZODIOXOL-5-YL)-5-(2-PYRIDINYL)-1H-IMIDAZOL-2-YL]BENZAMIDE | SB431542 | SB-431542 | 4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide | SB 431542

CAS number

301836-41-9

molecular formula

C22H16N4O3

molecular weight

384.39 g/mol

Exact mass

PSA

103.000 Å²

Logp

2.700

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