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Product introduction

SB525334是一种有效的，选择性的TGFβ receptor I (ALK5)抑制剂，IC50为14.3 nM，作用于ALK4比作用于ALK5效果低4倍，可抑制ALK2， 3，和6活性。A potent ATP-competitive inhibitor against receptor TbR-I/ALK5. SB525334 is a potent and selective inhibitor of TGFβ receptor I (ALK5) with IC50 of 14.3 nM, is 4-fold less potent to ALK4 than ALK5 and inactive to ALK2, 3, and 6.

Specs ⸢ View details ⸥

Chinese name

SB525334,TGFBR1抑制剂

English name

SB525334

Chinese alias

6-[2-(叔丁基)-5-(6-甲基吡啶-2-基)-1H-咪唑-4-基]喹喔啉

English alias

6-(2-(tert-Butyl)-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)quinoxaline

CAS number

356559-20-1

molecular formula

C21H21N5

molecular weight

343.42 g/mol

Exact mass

≥98%

PSA

67.400 Å²

Logp

3.7

Technical Documents

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