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Product introduction

Information SR-717 lithium SR-717 lithium is a non-nucleotide STING agonist that demonstrates broad interspecies and interallelic specificity with EC50 of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 (cGAS KO) cell lines, respectively. SR-717 lithium also induces the expression of clinically relevant targets, including programmed cell death 1 ligand 1 (PD-L1), in a STING-dependent manner. SR-717 lithium exhibits antitumor activity. Targets STING (in ISG-THP1 (WT) cells); STING (in ISG-THP1 (cGAS KO) cells) 2.1 μM(EC50); 2.2 μM(EC50)

Specs ⸢ View details ⸥

Chinese name

SR-717 lithium

English name

SR-717 lithium

Chinese alias

English alias

Benzoic acid,4,5-difluoro-2-[[[6-(1H-imidazol-1-yl)-3-pyridazinyl]carbonyl]amino]-,lithium salt (1:1)

CAS number

2375421-09-1

molecular formula

C15H8F2LiN5O3

molecular weight

351.19 g/mol

Exact mass

≥98%

PSA

113.000 Å²

Logp

1.765

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