Friedel-Crafts 酰化反应、Diels-Alder 反应以及其他碳-碳键形成反应的重要催化剂。用立体化学方法催化丙烯酸酯的自由基聚合反应。非常活泼、有效、可再生和再利用的酰化催化剂。 在Friedel-Crafts 酰化、 Diels-Alder 反应和其它的有碳-碳键构成的反应中是重要的催化剂。与三乙基硅烷共同用于官能化吡喃糖苷环的还原性开环反应。用于通过稳定的硫叶立德合成三环[3.3.2.02,8]癸-6,9-二烯-3-酮(8CI,9CI) 的关键步骤的路易斯酸。 Scandium(III) triflate is an important catalyst for Friedel-Crafts acylation, Diels-Alder reactions and other carbon-carbon bond-forming reactions. It also stereochemically catalyzes the radical polymerization of acrylates.Scandium(III) triflate complex of (4′S,5′S)-2,6-bis[4′-(triisopropylsilyl)oxymethyl-5′-phenyl-1′,3′-oxazolin-2′-yl]pyridine has been employed as catalyst for the asymmetric Friedel-Crafts reaction between substituted indoles and methyl (E)-2-oxo-4-aryl-3-butenoates. Scandium(III) triflate was used as catalyst in the following studies: . Hydrothiolation reaction of aromatic and aliphatic thiols. . Selective two-electron reduction of O2 by ferrocene derivatives. . Vinylogous Friedel-Crafts alkylation of indoles and pyrroles in water. . Synthesis of β-cyanoketones. It was also used with triethylsilane to reductively open functionalized pyranoside rings and in the key step of synthesis of bullvalone via a stabilized sulfur ylide.