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Product introduction

Nutlin-3是一种有效的，选择性的Mdm2(依赖环指状的泛素蛋白连接酶和p53)拮抗剂，IC50为90 nM。可稳定p53缺陷的细胞中的p73。Disrupts MDM2-p53 interaction, inducing apoptosis. Nutlin-3 is a potent and selective Mdm2 (RING finger-dependent ubiquitin protein ligase for itself and p53) antagonist with IC50 of 90 nM; stabilizes p73 in p53-deficient cells. Disrupts MDM2-p53 interaction, inducing apoptosis.

Specs ⸢ View details ⸥

Chinese name

Nutlin-3,MDM2拮抗剂

English name

Nutlin-3

Chinese alias

English alias

NSC732664 | NSC-732664 | SW220144-1 | 4-[4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one | AKOS005146527 | FT-0771774 | SB19407 | SB19406 | Nutlin 3(Random Configuration) | Nutln 3A | (Rac)-Nutl

CAS number

548472-68-0

molecular formula

C30H30Cl2N4O4

molecular weight

581.49 g/mol

Exact mass

≥98%

PSA

83.500 Å²

Logp

5.200

Technical Documents

548472-68-0 | Nutlin-3.pdf
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