15-酮-前列腺素F2α是PGF2α的首个代谢产物，由15-羟基前列腺素脱氢酶（15-羟基PGDH）生物合成。该化合物被认为是金鱼和大西洋鲑鱼排卵后信息素中的关键成分之一，并已显示出能刺激它们的嗅觉受体。据报道，在兔眼压降低时，15-酮-前列腺素F2α的活性比PGF2α低10倍；然而，由于在生理条件下半衰期延长，因此前列腺素代谢物可能具有重要的生物学功能。 15-Keto-prostaglandin F2α is the first metabolite of PGF2α, biosynthesized by 15-hydroxy prostaglandin dehydrogenase (15-hydroxy PGDH). This compound is believed to be one of the critical components in the postovulatory pheromone for goldfish and Atlantic salmon, and has been shown to stimulate their olfactory receptors. 15-Keto-prostaglandin F2α is reportedly 10-folds less active than PGF2α at decreasing rabbit intraocular pressure; however, prostaglandin metabolites may have important biological functions due to an increased half-life under physiological conditions.