应用 2,2,6,6-四甲基哌啶锂是一种强碱，可用于：以反式-α-锂化环氧化物为中间体，从末端环氧化物合成烯胺。芳烃的邻位锂化，如1，3-双（三氟甲基）苯、4，4-二甲基-2-苯基-2-恶唑啉、1，4-双（三氟甲基）苯和1，3-二甲氧基苯。与Lewis供体配体N,N,N′,N′-四甲基乙二胺（TMEDA）结合，将甲氧基取代的芳烃进行去质子金属化。 Description Lithium 2,2,6,6-tetramethylpiperidide is a strong base and can be used:For the synthesis of enamines from terminal epoxides throughtrans-α-lithiated epoxide as an intermediate.For ortholithiation of arenes such as 1,3-bis(trifluoromethyl)benzene, 4,4-dimethyl-2-phenyl-2-oxazoline, 1,4-bis(trifluoromethyl)benzene and 1,3-dimethoxybenzene.In combination with Lewis donor ligand,N,N,N′,N′-tetramethylethylenediamine (TMEDA) for deprotonative metalation of methoxy-substituted arenes.