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Product introduction
托美汀是一种单羧酸,是在吡咯环的5位被4-甲基苯甲酰基取代的(1-甲基吡咯-2-基)乙酸。以其二水合钠盐形式用作非选择性非甾体抗炎药。它具有非甾体抗炎药和EC 1.14.99.1(前列腺素-内过氧化物合酶)抑制剂的作用。它是一种单羧酸、吡咯类化合物和芳香酮。它是托美汀(1-)的共轭酸。
Chinese name
托麦汀
English name
2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetic acid
Chinese alias
-
English alias
BPBio1_000959 | Tolmetina | BIDD:GT0468 | CCG-267033 | DTXSID2043951 | KBioSS_001415 | Tolmetino [INN-Spanish] | 2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetic acid | KBio2_001415 | MFCD00599595 | SCHEMBL3150 | D02355 | KBio2_006551 | KBio3_001606 | Op
CAS number
26171-23-3
molecular formula
C15H15NO3
molecular weight
257.28
Exact mass
-
PSA
59.3
Logp
2.8
Safety
  • interaction: 尽管它与白蛋白广泛结合...当华法林和托美汀一起给药时,凝血酶原时间没有变化。
  • Hepatotoxicity: 可能性评分:D(可能,罕见的临床明显肝损伤原因)。
  • Special Reports: 非甾体抗炎剂的研究与开发史,包括托美汀。[GRINGAUZ A; 非甾体抗炎剂--太阳底下有什么新东西?; HOSP FORMUL 14(MAR) 290 (1979)]
  • Other safety information: 化学品评估:IMAP评估 - 1H-吡咯-2-乙酸,1-甲基-5-(4-甲基苯甲酰基)-:人类健康I级评估
  • Hazard categories and classifications: STOT SE 3 (66.7%)
  • Non-human toxic extract: 托美汀(100-150微克/升)剂量依赖性地抑制小鼠脾细胞和人淋巴细胞在体外的DNA合成。
  • Drug Induced Liver Injury: 参考文献:DOI:10.1016/j.drudis.2019.09.022
  • Effects During Pregnancy and Lactation: ◉ 对哺乳和母乳的影响
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Research chemical CAS 26171-23-3 1ml

Yuanye Research chemical CAS 26171-23-3 1ml, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.

item number:S55784-1ml
Product model:1ml
level: 1ml
Lead Time:30days
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