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Product introduction
AR-42 (OSU-HDAC42),hydroxamate-tethered phenylbutyrate的衍生物,是一种新型有效的组蛋白去乙酰化酶(HDAC)抑制剂,有效抑制HDAC的活性,IC50值为16 nM,诱导组蛋白H3乙酰化,α-微管蛋白乙酰化和p21的上调,这些被视为HDAC抑制的标志性指标。据报道,AR-42调节几个细胞凋亡抑制剂以及细胞存活调节剂,包括Akt、Bcl-xL、Bax、Ku70和Surviving,通过对PI3K/Akt信号通路的至少部分抑制,对多种肿瘤类型具有有效的抗肿瘤活性,如人前列腺癌和肝癌。 AR-42 (HDAC-42) 是一种HDAC抑制剂,IC50为30 nM。
Chinese name
AR-42,HDAC抑制剂
English name
AR-42
Chinese alias
-
English alias
AC-5612 | DB12707 | NCGC00263153-01 | CCG-208672 | NCGC00263153-05 | AR-42 - HDAC-42 | CHEBI:188197 | (S)-HDAC 42 | AR 42 | UNII-E0GG29V0AQ | HMS3648K08 | N-hydroxy-4-[[(2S)-3-methyl-2-phenylbutanoyl]amino]benzamide | BCP9000313 | OSU-HDAC42 | E0GG29V0AQ
CAS number
935881-37-1
molecular formula
C18H20N2O3
molecular weight
312.36 g/mol
Exact mass
≥98%
PSA
78.400 Ų
Logp
2.8
Technical Documents
「No technical documents」
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Research chemical CAS 935881-37-1 AR 1ml

Yuanye Research chemical CAS 935881-37-1 AR 1ml, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.

item number:S59276-1ml
Product model:1ml
level: AR 1ml
Lead Time:30days
sold 590 Items
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