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Product introduction
倍他洛尔是一种丙醇胺,是 3-氨基丙烷-1,2-二醇,其中伯羟基的氢被 4-[2-(环丙基甲氧基)乙基]苯基取代,氨基上的一个氢被异丙基取代。它是一种选择性 β1-受体阻滞剂,用于治疗青光眼以及高血压、心律失常和冠心病。它也用于减少心力衰竭患者非致命性心脏事件。它具有 β-肾上腺素能拮抗剂、降压药和抗交感神经药的作用。
Chinese name
倍他洛尔
English name
1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-(propan-2-ylamino)propan-2-ol
Chinese alias
-
English alias
1-[4-[2-(Cyclopropylmethoxy)ethyl]phenoxy]-3-(propan-2-ylamino)propan-2-ol
CAS number
63659-18-7
molecular formula
C18H29NO3
molecular weight
307.4
Exact mass
-
PSA
50.7
Logp
2.8
Safety
  • Harmful effect: 麻醉剂:当与抑制心肌的麻醉剂(如异氟烷和丙泊酚)联合使用时,必须谨慎考虑使用倍他洛尔。
  • Toxicity summary: 尽管倍他洛尔是一种选择性β-1受体拮抗剂,但其过量症状与其他β-阻滞剂(包括非选择性药物)相似。这种相似性是因为倍他洛尔在较高的治疗水平下会失去其选择性,并开始与β-2和β-3受体结合。β-阻滞剂的过量与抑郁有关。三分之二的β-阻滞剂过量者正在服用非处方药物。对于危及生命的倍他洛尔过量,可能需要体外循环支持。
  • Hepatotoxicity: 可能性评分:E(不太可能引起明显的肝损伤)。
  • Hazard categories and classifications: 水生慢性 3 (100%)
  • Drug Induced Liver Injury: 参考文献:DOI:10.1016/j.drudis.2019.09.022
  • Effects During Pregnancy and Lactation: 截至修订日期,未找到关于正常哺乳期间β-阻滞或倍他洛尔相关影响的已发表信息。一项对6名高催乳素血症和溢乳患者的研究发现,用普萘洛尔进行β-肾上腺素能阻滞后,血清催乳素水平没有变化。
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Research chemical CAS 63659-18-7 1ml

Yuanye Research chemical CAS 63659-18-7 1ml, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.

item number:S59308-1ml
Product model:1ml
level: 1ml
Lead Time:30days
sold 90 Items
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