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Product introduction
Linsitinib is a potent, selective insulin-like growth factor-1 receptor (IGF-1R, IC50 = 35 nM) and insulin receptor (IR, IC50 = 75 nM) kinase inhibitor which works to block the autophosphorylation of IGF-1R and IR. Additionally, in vitro studies of Linsitinib have demonstrated its ability to inhibit the proliferation of multiple tumor cell lines.Linsitinib is a selective inhibitor of IGF-1R with IC50 of 35 nM, and modestly potent to InsR with IC50 of 75 nM, and has no activity towards Abl, ALK, BTK, EGFR, FGFR1/2, PKA etc.
Chinese name
OSI-906(Linsitinib),双重IGF-1R和胰岛素受体激酶抑制剂, 胰岛素样生长因子 I 受体抑制剂 胰岛素受体抑制剂 胰岛素受体相关受体抑制剂
English name
OSI-906 (Linsitinib)
Chinese alias
顺式-3-[8-氨基-1-(2-苯基-7-喹啉基)咪唑并[1,5-A]吡嗪-3-基]-1-甲基环丁醇
English alias
Linsitinib (USAN/INN) | Cis-3-(8-Amino-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl)-1-methylcyclobutan-1-ol | HMS3295G15 | Kinome_3532 | CHEBI:91402 | (1s,3s)-3-(8-amino-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl)-1-methylcyclobutanol | S
CAS number
867160-71-2
molecular formula
C26H23N5O
molecular weight
421.51 g/mol
Exact mass
-
PSA
89.300 Ų
Logp
4.200
Technical Documents
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Research chemical CAS 867160-71-2 1ml

Yuanye Research chemical CAS 867160-71-2 1ml, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.

item number:S59455-1ml
Product model:1ml
level: 1ml
Lead Time:30days
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