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名称

磺基DBCO-马来酰亚胺（Mal-Sulfo-DBCO ）TEA盐

英文别名

Mal-Sulfo-DBCO | 1-[[3-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-3-oxopropyl]amino]-3-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]-1-oxopropane-2-sulfonic acid | Sulfo DBCO maleimide

英文名称

Sulfo DBCO-Maleimide（Mal-Sulfo-DBCO ）TEA salt

货号

S596201-25mg

包装规格

25mg

浓度

≥95%

储存温度

-20°C储存,充氩

运输条件

超低温冰袋运输

产品介绍

磺基DBCO马来酰亚胺是一种水溶性巯基反应物，含有马来酰亚胺基团和DBCO部分。马来酰亚胺基团与硫醇特异有效地反应形成稳定的硫醚键。低质量重量将为改性分子添加最小的间隔物，并将使DBCO部分能够简单有效地掺入含半胱氨酸的肽或其他含巯基的生物分子上。DBCO通常用于无铜的点击化学反应。 Sulfo DBCO-Maleimide a water-soluble sulfhydryl reactive containing a maleimide group and a DBCO moiety. Maleimide group specifically and efficiently reacts with thiols to form stable thioether bonds. The low mass weight will add minimal spacer to modified molecules and will enable simple and efficient incorporation of DBCO moiety onto cysteine-containing peptides or other thiol-containing biomolecules. DBCO is commonly used for copper-free Click Chemistry reactions.

生化机理

Mal-Sulfo-DBCO 是一种可降解 (cleavable) 的 ADC linker，可用于合成抗体偶联活性分子 (ADC)。Mal-Sulfo-DBCO 是一种点击化学试剂。它含有 DBCO 基团，可以和含有 Azide 基团的分子发生环张力 (strain) 促进的炔-叠氮环加成反应 (SPAAC)。

CAS号

2028281-86-7(free base)

分子式

C28H26N4O8S(free base)

分子量

578.6(free base) g/mol

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

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「No technical documents」

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