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突变的G551D CFTR校正器。VRT-532通过增强突变体的ATP亲和力介导G551D-CFTR。VRT-532还可以增强F508del突变的CFTR，并专门针对突变CFTR而不是其他膜蛋白。‘ VRT-532 (CFpot-532)是CFTR 的有效调节剂，常用于CFTR 缺陷引起的囊性纤维化(CF)研究。降解囊性纤维化中积累的硫酸化糖胺聚糖(gag)所必需的Arylsulfatase B (ARSB)，小分子调节剂VRT-532对CFTR 的修饰能增加ARSB 并减少4-硫酸软骨素的积累。 ’ A mutated G551D CFTR corrector. VRT-532 mediates G551D-CFTR by enhancing ATP affinity of the mutant. VRT-532 also potentiates F508del mutated CFTR and works specifically on mutant CFTR rather than other membrane proteins.

Specs ⸢ View details ⸥

Chinese name

VRT-532

English name

VRT-532

Chinese alias

CFpot-532

English alias

4-methyl-2-(3-phenyl-1H-pyrazol-5-yl)phenol | 4-Methyl-2-(5-phenyl-1H-pyrazol-3-yl)phenol | VRT 532 | VRT532

CAS number

38214-71-0

molecular formula

C16H14N2O

molecular weight

250.29 g/mol

Exact mass

PSA

48.900 Å²

Logp

3.500

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Research chemical CAS 38214-71-0 ≥95% 5mg

Name: Research chemical CAS 38214-71-0 ≥95% 5mg
Brand: 源叶
SKU: S59863-5mg

Yuanye Research chemical CAS 38214-71-0 ≥95% 5mg, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.

item number：S59863-5mg

Product model：5mg

level： ≥95% 5mg

Lead Time：30days

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Research chemical CAS 38214-71-0 ≥95% 5mg

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