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Product introduction
PD158780是一种吡啶并嘧啶,是4,6-二氨基吡啶并[3,4-d]嘧啶,其中4位和6位的氨基分别被间溴苯基和甲基取代。它是EGFR酪氨酸激酶活性的强效、细胞可渗透、可逆ATP竞争性抑制剂[对EGFR、ErbB2(HER2)和Erb4(HER4)的IC50值分别为0.008、49和52 nM]。它不抑制FGF或PDGF介导的酪氨酸磷酸化。在MCF10A细胞中诱导G1细胞周期停滞,并在A431人表皮癌细胞中具有抗增殖作用。它是一种抗肿瘤药物和EC 2.7.10.1(受体蛋白酪氨酸激酶)抑制剂。它是一种二胺、芳香胺、溴苯类化合物、吡啶并嘧啶和仲...
Chinese name
-
English name
4-N-(3-bromophenyl)-6-N-methylpyrido[3,4-d]pyrimidine-4,6-diamine
Chinese alias
-
English alias
-
CAS number
171179-06-9
molecular formula
C14H12BrN5
molecular weight
330.18
Exact mass
-
PSA
62.7
Logp
3.4
Safety
  • Hazard categories and classifications: 急性毒性 4级 (100%)
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PD158780 ≥98% 10mg

Yuanye PD158780 ≥98% 10mg, CAS 171179-06-9, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.

item number:S62589-10mg
Product model:10mg
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Lead Time:30days
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