6-Methylindole is a reactant for preparation of aminoguanidine derivatives of arylsulfonylacylindoles, indolylindazoles and indolylpyrazolopyridines as interleukin-2 inducible T cell kinase inhibitors and tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles. · Reactant for preparation of tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators · Reactant for preparation of indole linked triazole derivatives as antifungal agents · Reactant for preparation of N-β-D-xylosyl-indole derivatives as SGLT2 inhibitors for management of hyperglycemia in diabetes · Reactant for preparation of aminoguanidine derivatives of arylsulfonylacylindoles as antifungal agents · Reactant for preparation of indolylindazoles and indolylpyrazolopyridines as interleukin-2 inducible T cell kinase inhibitors · Reactant for preparation of arylsulfonylacetylindoles as anti-HIV-1 agents 6-Methylindole was used in the synthesis of benz[c,d]indol-3(1H)-one derivatives. 6-Methylindole is a reactant for preparation of aminoguanidine derivatives of arylsulfonylacylindoles, indolylindazoles and indolylpyrazolopyridines as interleukin-2 inducible T cell kinase inhibitors and tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles. · Reactant for preparation of tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators · Reactant for preparation of indole linked triazole derivatives as antifungal agents · Reactant for preparation of N-β-D-xylosyl-indole derivatives as SGLT2 inhibitors for management of hyperglycemia in diabetes · Reactant for preparation of aminoguanidine derivatives of arylsulfonylacylindoles as antifungal agents · Reactant for preparation of indolylindazoles and indolylpyrazolopyridines as interleukin-2 inducible T cell kinase inhibitors · Reactant for preparation of arylsulfonylacetylindoles as anti-HIV-1 agents 6-Methylindole was used in the synthesis of benz[c,d]indol-3(1H)-one derivatives.