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Product details

名称

SNT-207858 free base

别名

SNT-207858 游离碱

英文名称

SNT-207858 free base

货号

S647413-5mg

包装规格

5mg

浓度

≥99%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

SNT207858 free base is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 ( MC-4 ) receptor antagonist. SNT207858 free base has an IC 50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor In Vitro SNT207858 binds to the MC-4 receptor with an affinity of 22 nM and shows a 170-fold selectivity vs. MC-3 and a 40-fold selectivity vs. MC-5. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo SNT207858 (30 mg/kg; oral administration; once daily; 15 days) significantly reduces the tumor induced weight loss in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Mice with C26 adenocarcinoma-induced cachexia model Dosage: 30 mg/kg Administration: Oral administration; once daily; 15 days Result: Significantly reduced the tumor induced weight loss. Form:Solid IC50& Target:MC-4 receptor

生化机理

SNT207858 游离碱是一种具有选择性、血脑屏障穿透性、强效和口服活性的黑色素皮质素-4（MC-4）受体拮抗剂。SNT207858 free base 对 MC-4 受体的 IC 50 值为 22 nM（结合）和 11 nM（功能）。

CAS号

1104662-66-9

分子式

C32H43Cl2N5O3

分子量

616.62 g/mol

PubChem编号

42630200

Isomeric SMILES

CC[C@H](COC1=C(N=CC=C1)C2CCN(CC2)C(=O)[C@@H](CC3=C(C=C(C=C3)Cl)Cl)NC(=O)N4CCCC4)N5CCCC5

IIUPAC Name

N-[(2R)-3-(2,4-dichlorophenyl)-1-oxo-1-[4-[3-[(2R)-2-pyrrolidin-1-ylbutoxy]pyridin-2-yl]piperidin-1-yl]propan-2-yl]pyrrolidine-1-carboxamide

INCHI

1S/C32H43Cl2N5O3/c1-2-26(37-14-3-4-15-37)22-42-29-8-7-13-35-30(29)23-11-18-38(19-12-23)31(40)28(36-32(41)39-16-5-6-17-39)20-24-9-10-25(33)21-27(24)34/h7-10,13,21,23,26,28H,2-6,11-12,14-20,22H2,1H3,(H,36,41)/t26-,28-/m1/s1

InChi Key

GNSVFEJLUPMLCZ-IXCJQBJRSA-N

Smiles

CCC(COC1=C(N=CC=C1)C2CCN(CC2)C(=O)C(CC3=C(C=C(C=C3)Cl)Cl)NC(=O)N4CCCC4)N5CCCC5

PubChem CID

42630200

溶解性

DMSO : 100 mg/mL (162.17 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

615.274 Da

单同位素质量Monoisotopic Mass

615.274 Da

拓扑极表面积Topological Polar Surface Area

78.000 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

863

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

5.5

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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