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Product details

名称

SLF

分子类型

小分子

英文名称

SLF

货号

S647692-5mg

包装规格

5mg

浓度

≥98%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

SLF is a synthetic ligand for FK506-binding protein (FKBP) with an affinity of 3.1 μM for FKBP51 and an IC 50 of 2.6 μM for FKBP12. SLF can be used in the synthesis of PROTAC . In Vitro Three scout fragments-KB02, KB03, and KB05 are fused, which cover two different electrophile groups (chloroacetamide and acrylamide) and display broad cysteine reactivity in the human proteome-to the SLF ligand that binds tightly and selectively to FKBP12, a cytosolic prolyl isomerase that has been frequently used to study ligand-induced protein degradation. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Oil

生化机理

SLF 是一种 FK506 结合蛋白（FKBP）的合成配体，对 FKBP51 的亲和力为 3.1 μM，对 FKBP12 的 IC 50 为 2.6 μM。SLF 可用于合成 PROTAC。

CAS号

195513-96-3

分子式

C30H40N2O6

分子量

524.65 g/mol

PubChem编号

35027274

Isomeric SMILES

CCC(C)(C)C(=O)C(=O)N1CCCC[C@H]1C(=O)O[C@H](CCC2=CC(=C(C=C2)OC)OC)C3=CC(=CC=C3)N

IIUPAC Name

[(1R)-1-(3-aminophenyl)-3-(3,4-dimethoxyphenyl)propyl] (2S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate

INCHI

1S/C30H40N2O6/c1-6-30(2,3)27(33)28(34)32-17-8-7-12-23(32)29(35)38-24(21-10-9-11-22(31)19-21)15-13-20-14-16-25(36-4)26(18-20)37-5/h9-11,14,16,18-19,23-24H,6-8,12-13,15,17,31H2,1-5H3/t23-,24+/m0/s1

InChi Key

IIDSDBBDZNDWCN-BJKOFHAPSA-N

Smiles

CCC(C)(C)C(=O)C(=O)N1CCCCC1C(=O)OC(CCC2=CC(=C(C=C2)OC)OC)C3=CC(=CC=C3)N

PubChem CID

35027274

溶解性

DMSO : 100 mg/mL (190.60 mM; ultrasonic and warming and heat to 60°C)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

524.289 Da

单同位素质量Monoisotopic Mass

524.289 Da

拓扑极表面积Topological Polar Surface Area

108.000 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

802.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

5.300

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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