SJF620 is a PROTAC connected by ligands for Cereblon and Btk with a DC 50 of 7.9 nM. SJF620 contains a Lenalidomide analog for recruiting CRBN In Vitro SJF620 is a PROTAC that retains potent degradation of BTK in cellular assays with a DC 50 of 7.9 nM in Burkitt lymphoma cell line NAMALWA. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo SJF620 has a super pharmacokinetic profile in mice (1 mg/kg; i.v.) with the half life (t 1/2 ) of 1.64 h. SJF620 exhibits a significantly better pharmacokinetic profile than MT802 . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Cereblon