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名称

SSTC3

英文名称

SSTC3

货号

S648238-5mg

包装规格

5mg

浓度

≥98%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

SSTC3 is a casein kinase 1α (CK1α) activator ( K d = 32 nM) that inhibits WNT signaling ( EC 50 = 30 nM). SSTC3 exhibits minimal gastrointestinal toxicity compared to other classes of WNT inhibitors. In Vitro SSTC3 (0-1μM, 5 days) decreases the viability of HCT116 cells in an on-target manner. This capacity is significantly reduced when the mutant CTNNB1 allele driving its carcinogenic properties is deleted. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: Colorectal cancer (CRC) cell lines. Concentration: 0-1 μM. Incubation Time: 5 days. Result: Decreased the viability. Western Blot AnalysisCell Line: SW403 cells. Concentration: 100 nM. Incubation Time: 15 min. Result: Increased β-catenin phosphate levels. In Vivo SSTC3 can be maintained for 24 hours after treatment . SSTC3 (25 mg/kg, ip once daily for 8-12 days) suppresses the growth of colorectal carcinoma in CD-1 mice . SSTC3 (10 mg/kg, ip once daily for 1 month) inhibits the growth of Apc mutation-driven tumors . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Five-week-old Apc min mice . Dosage: 10 mg/kg. Administration: IP for 1 month. Result: Inhibited the growth of Apc mutation-driven tumors. Animal Model: CD-1 mice. Dosage: 25 mg/kg. Administration: IP once daily for 8-12 days. Result: Inhibited the growth of HCT116 xenografts. Attenuated the growth of this metastatic CRC PDX and markedly reduced the cell density of residual cancer. Reduced the expression of WNT biomarkers in this CRC PDX. Form:Solid

生化机理

SSTC3 是一种酪蛋白激酶 1α (CK1α) 激活剂（K d = 32 nM），可抑制 WNT 信号转导（EC 50 = 30 nM）。与其他类别的 WNT 抑制剂相比，SSTC3 的胃肠道毒性极小。

CAS号

1242422-09-8

分子式

C23H17F3N4O3S2

分子量

518.53 g/mol

PubChem编号

46912682

Isomeric SMILES

CN(C1=CC=C(C=C1)C(F)(F)F)S(=O)(=O)C2=CC=C(C=C2)C(=O)NC3=NC(=CS3)C4=CC=CC=N4

IIUPAC Name

4-[methyl-[4-(trifluoromethyl)phenyl]sulfamoyl]-N-(4-pyridin-2-yl-1,3-thiazol-2-yl)benzamide

INCHI

1S/C23H17F3N4O3S2/c1-30(17-9-7-16(8-10-17)23(24,25)26)35(32,33)18-11-5-15(6-12-18)21(31)29-22-28-20(14-34-22)19-4-2-3-13-27-19/h2-14H,1H3,(H,28,29,31)

InChi Key

HSFAATUFWDDUGW-UHFFFAOYSA-N

Smiles

CN(C1=CC=C(C=C1)C(F)(F)F)S(=O)(=O)C2=CC=C(C=C2)C(=O)NC3=NC(=CS3)C4=CC=CC=N4

PubChem CID

46912682

MeSH Entry Terms

4-(N-methyl-N-(4-(trifluoromethyl)phenyl)sulfamoyl) benzoic acid;SSTC3

溶解性

DMSO : 125 mg/mL (241.07 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

518.069 Da

单同位素质量Monoisotopic Mass

518.069 Da

拓扑极表面积Topological Polar Surface Area

129.000 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

823.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

4.300

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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