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名称

SW157765

英文名称

SW157765

货号

S648694-5mg

包装规格

5mg

浓度

≥98%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

SW157765 is a selective non-canonical glucose transporter GLUT8 (SLC2A8) inhibitor. KRAS/KEAP1 double mutant NSCLC cells are selectively sensitive to the SW157765, due to the convergent consequences of dual KRAS and NRF2 modulation of metabolic and xenobiotic gene regulatory programs. In Vitro SW157765-sensitive NSCLC cell lines are also selectively sensitive to glucose deprivation and to GLUT8 depletion. SW157765 selectively inhibits fluorescent 2-deoxyglucose (2DG) uptake in SW157765-sensitive cells in a dose-dependent manner. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid

生化机理

SW157765 是一种选择性非典范葡萄糖转运体 GLUT8 (SLC2A8) 抑制剂。KRAS/KEAP1 双突变 NSCLC 细胞对 SW157765 有选择性的敏感性，这是由于 KRAS 和 NRF2 对代谢和异种生物的双重调节产生了趋同的结果。

CAS号

332063-87-3

分子式

C19H13N3O3

分子量

331.32 g/mol

PubChem编号

782267

Isomeric SMILES

C1=COC(=C1)/C=C/C(=O)NC2=CC3=C(C=C2)OC(=N3)C4=CC=NC=C4

IIUPAC Name

(E)-3-(furan-2-yl)-N-(2-pyridin-4-yl-1,3-benzoxazol-5-yl)prop-2-enamide

INCHI

1S/C19H13N3O3/c23-18(6-4-15-2-1-11-24-15)21-14-3-5-17-16(12-14)22-19(25-17)13-7-9-20-10-8-13/h1-12H,(H,21,23)/b6-4+

InChi Key

QSSYRORXXFTVFI-GQCTYLIASA-N

Smiles

C1=COC(=C1)C=CC(=O)NC2=CC3=C(C=C2)OC(=N3)C4=CC=NC=C4

PubChem CID

782267

溶解性

DMSO : 25 mg/mL (75.46 mM; ultrasonic and warming and heat to 60°C)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

331.096 Da

单同位素质量Monoisotopic Mass

331.096 Da

拓扑极表面积Topological Polar Surface Area

81.200 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

492

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

2.7

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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