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名称

SKF-34288 hydrochloride

别名

SKF-34288 盐酸盐

英文别名

FT-0671101 | 3-sulfanylpyridine-2-carboxylic acid;hydrochloride | AS-79457 | D94966 | AKOS027321159 | SKF-34288 hydrochloride | A904188 | HY-128923 | SKF-34288 (hydrochloride) | 3-Mercaptopicolinic acid (hydrochloride) | J-018609 | 3-Mercaptopicolinic Aci

英文名称

SKF-34288 hydrochloride

货号

S650474-5mg

包装规格

5mg

浓度

≥95%

储存温度

-20°C储存,干燥

运输条件

超低温冰袋运输

产品介绍

SKF-34288 (3-Mercaptopicolinic acid) hydrochloride is an orally active phosphoenolpyruvate carboxykinase ( PEPCK ) inhibitor ( K i : 2-9 μM). SKF-34288 hydrochloride is a potent hypoglycemic agent by inhibiting glucose synthesis. SKF-34288 hydrochloride also inhibits Asn metabolism and increases amino acids and amides In Vitro SKF-34288 hydrochloride (0.01-1 mM, 48 h) inhibits C2C12 cell proliferation . SKF-34288 hydrochloride (0.25-1 mM, 0-5 day) induces myogenic differentiation of C2C12 cells . SKF-34288 hydrochloride (0.25 or 1 mM) reduces mRNA expression of Pck2 and genes associated with serine biosynthesis . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay Cell Line: C2C12 cell Concentration: 0, 0.01, 0.1, 0.25, 0.5, 1 mM Incubation Time: 48 h Result: Dose-dependently inhibited C2C12 cell proliferation. In Vivo SKF-34288 hydrochloride (37.5-150mg/kg, p.o.) reduces blood glucose in starved rats . SKF-34288 hydrochloride (25 mg/kg, s.c.) neutralizes Salbutamol- mediated hyperglycaemia in rabbits. SKF-34288 hydrochloride (30 and 300 mg/kg, i.p.) reduces Pyruvate-induced blood glucose level in rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Starved rats Dosage: 37.5, 75 and 150mg/kg Administration: Oral administration (p.o.) Result: Showed dose-dependent magnitude and duration of the hypoglycaemic effect. Form:Solid IC50& Target:Ki: 2-9 μM (PEPCK)

生化机理

SKF-34288（3-巯基吡啶甲酸）盐酸盐是一种口服活性磷酸烯醇丙酮酸羧激酶（PEPCK）抑制剂（K i : 2-9 μM）。SKF-34288 盐酸盐可抑制葡萄糖合成，是一种强效降血糖药。SKF-34288 盐酸盐 a

CAS号

320386-54-7

分子式

C6H6ClNO2S

分子量

191.64 g/mol

PubChem编号

24721311

Isomeric SMILES

C1=CC(=C(N=C1)C(=O)O)S.Cl

IIUPAC Name

3-sulfanylpyridine-2-carboxylic acid;hydrochloride

INCHI

1S/C6H5NO2S.ClH/c8-6(9)5-4(10)2-1-3-7-5;/h1-3,10H,(H,8,9);1H

InChi Key

DYGYEUUVNLEHJP-UHFFFAOYSA-N

Smiles

C1=CC(=C(N=C1)C(=O)O)S.Cl

PubChem CID

24721311

溶解性

H2O : 5 mg/mL (26.09 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

190.981 Da

单同位素质量Monoisotopic Mass

190.981 Da

拓扑极表面积Topological Polar Surface Area

51.200 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

140.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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