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Product details

名称

SHIP2-IN-1

分子类型

小分子

别名

二合一运输

英文名称

SHIP2-IN-1

货号

S651632-5mg

包装规格

5mg

浓度

≥99%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

SHIP2-IN-1 is a potent SHIP2 inhibitor, inhibits SHIP2 activity, with an IC 50 of 2 µM. SHIP2-IN-1 blocks GSK3β activation by phosphorylation at the Ser9 residue. SHIP2-IN-1 is used in the research of Alzheimer’s disease In Vitro SHIP2-IN-1 (Compound 43; 10 µM) significantly inhibits PI(3,4)P2 production in HT22 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 2 µM (SHIP2)

生化机理

SHIP2-IN-1 是一种强效的 SHIP2 抑制剂，可抑制 SHIP2 的活性，IC50 为 2 µM。SHIP2-IN-1 可阻止 GSK3β 通过 Ser9 残基的磷酸化活化。SHIP2-IN-1 可用于阿尔茨海默病的研究。

CAS号

2252247-80-4

分子式

C17H13Cl2FN4O

分子量

379.2 g/mol

PubChem编号

138319691

Isomeric SMILES

C[C@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=CN=CC(=C2)C3=CN=C(N=C3)N

IIUPAC Name

5-[5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-3-yl]pyrimidin-2-amine

INCHI

1S/C17H13Cl2FN4O/c1-9(15-13(18)2-3-14(20)16(15)19)25-12-4-10(5-22-8-12)11-6-23-17(21)24-7-11/h2-9H,1H3,(H2,21,23,24)/t9-/m1/s1

InChi Key

ATPYDXUUBCDYKQ-SECBINFHSA-N

Smiles

CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=CN=CC(=C2)C3=CN=C(N=C3)N

PubChem CID

138319691

溶解性

DMSO : 100 mg/mL (263.70 mM; Need ultrasonic)

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

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