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Product details

名称

SB 258719

分子类型

小分子

英文别名

3,N-Dimethyl-N-[1-methyl-3-(4-methyl-piperidin-1-yl)-propyl]-benzenesulfonamide (SB-258719) | SB-258,719 | SCHEMBL2471088 | 3-METHYL-N-[(1R)-1-METHYL-3-(4-METHYL-1-PIPERIDINYL)PROPYL]-N-METHYLBENZENESULFONAMIDE HYDROCHLORIDE | Benzenesulfonamide, N,3-dime

英文名称

SB 258719

货号

S651783-5mg

包装规格

5mg

浓度

≥99%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

SB 258719 is a selective 5-HT 7 receptor antagonist with high affinity ( pK i =7.5) for the receptor. SB 258719 can be used for the research of cancer and neurological disease In Vitro SB 258719 (1, 3 and 10 μM; HEK 293 cells) produces a concentration-related rightward-shift of the 5-CT concentration-response curve with no signifcant alteration in the maximal response to 5-CT. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo SB 258719 (5-20 mg/kg; i.p.) significantly attenuates the 5-CT-induced hypothermia. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Swiss Webster mice (20-25 g). Dosage: 5-20 mg/kg Administration: I.p. Result: Significantly attenuated the 5-CT-induced hypothermia. Form:Liquid IC50& Target:5-HT 7 Receptor 7.5 (pKi)

生化机理

SB 258719 是一种选择性 5-HT 7 受体拮抗剂，对该受体具有高亲和力（pK i =7.5）。SB 258719 可用于癌症和神经系统疾病的研究。

CAS号

195199-95-2

分子式

C18H30N2O2S

分子量

338.51 g/mol

PubChem编号

5312148

Isomeric SMILES

CC1CCN(CC1)CC[C@@H](C)N(C)S(=O)(=O)C2=CC=CC(=C2)C

IIUPAC Name

N,3-dimethyl-N-[(2R)-4-(4-methylpiperidin-1-yl)butan-2-yl]benzenesulfonamide

INCHI

1S/C18H30N2O2S/c1-15-8-11-20(12-9-15)13-10-17(3)19(4)23(21,22)18-7-5-6-16(2)14-18/h5-7,14-15,17H,8-13H2,1-4H3/t17-/m1/s1

InChi Key

AGVNHDNTFYHZNL-QGZVFWFLSA-N

Smiles

CC1CCN(CC1)CCC(C)N(C)S(=O)(=O)C2=CC=CC(=C2)C

PubChem CID

5312148

溶解性

DMSO : 250 mg/mL (738.53 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

338.203 Da

单同位素质量Monoisotopic Mass

338.203 Da

拓扑极表面积Topological Polar Surface Area

49.000 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

452

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

3.5

RIDADR

NONHforallmodesoftransport

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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