S-23

小分子

S-23

S654608-1ml

1ml

10mM in DMSO

-80℃储存

超低温冰袋运输

S-23 is an orally active selective androgen receptor modulator (SARM) with a K i of 1.7 nM. S-23 induces androgen receptor (AR)-mediated transcriptional activation in CV-1 cells. S-23 increases prostate, seminal vesicle, and levator ani muscle weights in castrated rats In Vitro S-23 induces AR-mediated transcriptional activation in CV-1 cells when used at a concentration of 10 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo By administration of S-23 to castrated animals, androgen-dependent organ weights increased in a dose-dependent manner. The ED 50 of S-23 in the prostate and levator ani muscle is 0.43 and 0.079 mg/d, respectively . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Sprague Dawley rats (in castrated male rats) Dosage: 0.01-3 mg Administration: S.c.; daily for 14 d Result: Androgen-dependent organ weights increased in a dose-dependent manner. At a dose rate as low as 0.1 mg/d, S-23 is able to selectively maintain the weight of the levator ani muscle at the intact control level, whereas its effects on the prostate and seminal vesicles are lower than 30% of those observed in intact controls. IC50& Target:Ki: 1.7 nM (Androgen receptor)

S-23 是一种口服活性选择性雄激素受体调节剂（SARM），其 K i 为 1.7 nM。S-23 能诱导 CV-1 细胞中雄激素受体（AR）介导的转录激活。S-23 可增加前列腺、精囊和阴茎背肌的重量。

1010396-29-8(DMSO)

C18H13ClF4N2O3

416.75 g/mol

CC(COC1=CC(=C(C=C1)Cl)F)(C(=O)NC2=CC(=C(C=C2)C#N)C(F)(F)F)O

26002387